What regenerative treatments do
A small sample of your blood is spun in a centrifuge to concentrate platelets, which carry growth factors that signal repair. PRP (platelet-rich plasma) is a liquid injected or needled into the skin. PRF (platelet-rich fibrin) is spun more slowly without anticoagulant, so it forms a soft gel that releases growth factors over days and can be placed where filler is risky, such as the under-eye.
PDRN (polydeoxyribonucleotide) is a DNA fragment derived from salmon that stimulates fibroblasts and improves microcirculation. It is widely used in Korea and Europe for skin repair and hydration.
None of these add volume in the way filler does. They are used to try to improve the quality of what is there, such as texture, tone and fine lines, and results vary from person to person.
PRP, PRF or PDRN
Chosen by area and goal; often combined with microneedling or placed after filler.
| Treatment | Source | Best for | Form | Status |
|---|---|---|---|---|
| PRP | Your blood, centrifuged | Skin texture, fine lines, hair thinning; microneedling add-on | Liquid | Own tissue |
| PRF | Your blood, slow spin, no additives | Under-eye hollows and dark circles, cheeks, acne scars | Gel, injected | Own tissue |
| PDRN | Salmon DNA fragments | Skin repair, hydration, redness, post-procedure healing | Liquid, injected or needled | Not FDA-approved |
PRP and PRF are prepared from your own blood. The preparation system is FDA-cleared; the treatments themselves are not FDA-approved for these uses. PDRN has no FDA approval for injection.
No foreign material means minimal allergy risk and no possibility of a lump of product. The result is a change in your skin, which is why it builds over weeks.
Three sessions four weeks apart, then one or two a year. Results depend on your own healing response and vary more than with filler.
Areas treated
| Area | Typical treatment | Status |
|---|---|---|
| Under-eye hollows and shadows | PRF, 2 to 3 sessions | Own tissue |
| Full face skin quality | PRP with microneedling, 3 sessions | Own tissue |
| Neck and jawline crepiness | PRF or PDRN, 3 sessions | Own tissue |
| Acne scars | PRP with microneedling | Own tissue |
| Hair thinning | PRP scalp injections, 3 to 4 sessions | Own tissue |
| Redness and barrier repair | PDRN, 3 sessions | Not FDA-approved |
Plans are written per session.
Who it is for
- Dullness, fine lines or crepey texture rather than volume loss
- Dark circles or hollows where filler feels too risky
- You want to improve skin before an event season
- You prefer no foreign material
- Pregnant or breastfeeding
- Blood disorders, anticoagulant therapy, low platelet count
- Active infection, cold sore or cancer under treatment
- Fish allergy (PDRN)
- Replace lost volume; see fillers and collagen stimulators
- Deliver a visible result in one visit
- Lift loose skin
How much do PRP, PRF and PDRN cost?
Priced per session and planned as a series of three. Your written quote lists the treatment, area, number of sessions and total. Series plans require a deposit, applied to the first session.
Prices are confirmed at consultation and stated with their effective dates. Any offer carries its start and end dates. How pricing works.
What happens, step by step
- ConsultationAssess skin and goals
Which treatment suits the area, how many sessions, and what to combine it with.
- Day 0Draw, spin, treat
Blood draw (one to three small tubes), 10 to 15 minutes in the centrifuge, numbing, then injection or microneedling. About an hour.
- Days 1 to 2Settling
Redness, small bumps, mild swelling under the eyes. Make-up the next day. No sauna or heavy exercise for 24 hours.
- Weeks 4 and 8Sessions 2 and 3
Each session builds on the last. Texture and tone improve between visits.
- Months 3 to 12Result and maintenance
Full result 2 to 3 months after the last session. One or two sessions a year maintain it.
Risks and side effects
Common: redness, swelling, bruising at the draw and treatment sites for one to three days; under-eye PRF can look puffy for up to a week. Uncommon: infection, prolonged swelling. PDRN carries a small allergy risk for people sensitive to fish. There is no risk of product migration or vascular blockage from PRP or PRF, since they are liquid or soft gel.
Full informed consent is reviewed before treatment.
Questions about regenerative treatments
Related treatments
Hollows, shadows and crepiness assessed by cause; filler is often the wrong tool.
Microneedling for pore size, texture and glow, planned around your event date.
References: FDA list of approved dermal fillers (PDRN is not on it) · FDA consumer alert on regenerative medicine products · FDA clearance records for the preparation systems used. Individual results vary. This page is educational and not a substitute for a consultation.
